First developed in the 1950s, Formula IV with Tre-en-en® Grain Concentrates has provided people worldwide with decades of nutritional assurance at the cellular level.

Exclusive Tre-en-en® Grain Concentrates form the basis for this complete, natural whole-food supplement.

More than a multi-vitamin, a unique multi-factor whole-food supplement with vitamins (including 400 mcg of folic acid), minerals, lipids & sterols, and enzymes.

Supported by research which shows that adequate amounts of lipids and sterols promote better nutrient utilization, cardiovascular development, and increased endocrine activity.*

With natural coloring and preservative-free. Phyto-Enzyme Blend: Exclusive plant-sourced enzymes support easy digestion and absorption of supplemented nutrients.

Non-active ingredients: Gelatin, glycerin, wax, water, hydrolyzed collagen protein, titanium dioxide and natural color.
Contains: soy, wheat, and fish (pollack and skipjack).

A. Formula IV and Formula IV Plus are not just your average vitamin and mineral supplements; they’re multi-factor food supplements, designed formulated to feed the cells of your body.

When we first introduced Formula IV, it was originally intended to help fill in the nutritional gaps that can occur with the diets of everyday people. Today this basic premise still holds true; the times have changed, but our bodies are still biologically the same. As a matter of fact, the mix of nutrients contained within Formula IV, and our newer Formula IV Plus, is more valid today than ever before. Our contemporary lifestyle and dietary habits have created a greater need for the exact nutrients that are found in these two products. We have known from the beginning that Formula IV includes those nutrients that are beneficial to achieving optimum health, and it is truly in a class all its own. This holds true for Formula IV Plus, as well. Moreover, consuming Formula IV and Formula IV Plus really is more similar to eating food than simply taking a multi-vitamin supplement.

Unlike multi-vitamin products that often provide “megadoses” of certain nutrients, Formula IV and Formula IV Plus provide a balance of nutrients that is considered optimal for the vast majority of people. For those individuals who desire specific combinations of certain nutrients, we offer a wide variety of products to meet each individual’s unique needs; a perfect example would be our Daily Vitality Packs, which utilize Formula IV Plus as their core supplement.

At the foundation of Formula IV and Formula IV Plus is our exclusive Tre-en-en Grain Concentrates. The Tre-en-en Grain Concentrates contained within these two products help to support the body in its utilization of nutrients critical to sustain health and vitality. Lipids and sterols are the building blocks for every cell membrane in the human body. Sterols are a class of lipids which include precursors of certain hormones and precursors of vitamin D produced naturally in the body. Without properly balanced lipid/sterol levels, cells can become malnourished, which can lead to cellular fatigue. Sterols and lipids also play a vital role in the assimilation of nutrients by the cell.
 

Q. Why aren’t the minerals in Formula IV or Formula IV Plus chelated?

A. Time tested and proven to be effective and highly bioavailable, Formula IV and Formula IV Plus were developed as multi-factor whole food supplements, with Tre-en-en Grain Concentrates, to support optimal cellular nutrition. These GNLD exclusives have remained unchanged. Chelation mineral technology came after Formula IV’s introduction, however since both Formula IV and Formula IV Plus have a long history of effectiveness in supporting optimal health through cellular nutrition, we have no need or desire to change them.
 

Q. Is there any gamma linolenic acid in Formula IV or Formula IV Plus?

A. Formula IV and Formula IV Plus contain linoleic acid which can be converted to gamma-linolenic acid by the body during metabolism. GNLD does not add gamma-linolenic acid to any of our products, including Formula IV and Formula IV Plus. The body will naturally produce gamma-linolenic acid from linoleic acid, an important component of Formula IV and Formula IV Plus.
 

Q. What makes Formula IV green?

A. The green color in Formula IV is derived from the natural vegetable pigment, chlorophyll.
 

Q. What information do we have on the initial studies done on Formula IV? Was it a government grant study?

A. The research that eventually led to the development of Formula IV began in 1946 at a hospital in Southern California. The focus of the research was on the relationship of endocrine function to reports of chronic fatigue. The results of many studies led researchers to the role of lipids in cell function; and that in turn led to the development of Tre-en-en Concentrates. Formula IV was developed as a multi-factor nutritional supplement, designed to work with the lipids and sterols provided by Tre-en-en. Now the cornerstone of our “Energy Program,” Formula IV (and now also Formula IV Plus) have been credited with giving literally thousands of consumers more energy, vitality, and a general feeling of health and wellness!
 

Q. I read somewhere that it is not good to take iron in a multi-supplement formula. If this is true, then why is iron in Formula IV?

A. We’re not sure why anyone would have stated that iron should not be part of a multivitamin supplement. Iron-deficient diets are still widespread in our population and anemia remains a common health concern. For this reason, Formula IV was formulated to contain a sufficient amount of iron to assure that an adequate and healthy amount of this nutrient is supplied through supplementation. Additionally, Formula IV has been specifically formulated to maximize digestion and absorption of iron. If you are concerned about iron intake and would like an iron-free option, consider Formula IV Plus for your supplementation needs.
 

Q. What are the sources for all the ingredients in Formula IV and Formula IV Plus?

A. Formula IV and Formula IV Plus are not just vitamin and mineral supplements; they are multi-factor food supplements, chock-full of whole food ingredients. Besides containing many of the important vitamins and minerals missing from our diets, they also contain our exclusive Tre-en-en Grain Concentrates. Tre-en-en is the largest component of Formula IV and Formula IV Plus, and the sources are listed on the label, as are many of the other sources of the nutrients used in these products. For example, fish liver oil, the source of vitamin A and vitamin D, is on the Formula IV label. Our approach to product formulation is to always look first to nature for 100% natural, whole food ingredients from the human food chain. Because some natural ingredients are weak, unstable, or unavailable, for some products we next look to natural concentrates or isolates to achieve our formulation goals. Lastly, if the two previous steps don’t deliver the effect we need, then we will select additional pure pharmaceutical-grade ingredients from a list of safe, low-allergy components. These are components which been shown by research to function effectively, providing superior bioavailabilty and overall nutritional excellence. This approach allows us to keep consistent with both nature’s blueprint and the latest scientific nutritional research. It is this approach to excellence that has contributed to GNLD’s distinction and success in the nutrition industry.
 

Q. Would the yeast in Formula IV and Formula IV Plus affect people with yeast allergies?

A. GNLD uses the unique whole-food source of yeast known as Saccharomyces cerevisiae, in Formula IV and Formula IV Plus. This special strain of yeast is “biologically bound” and highly concentrated in B-vitamins and other natural nutritional cofactors. This biologically bound yeast is grown specifically for nutritional application, and through a special process of growing, harvesting, and drying, a naturally high-potency B-vitamin source material is obtained. This is not a living yeast but rather (like the other food-based components in our nutritional products) it is an organic nutrient source that has been harvested and dried. And, as you may be aware, yeast has a long history of safe use, and has been used for decades by people as a source of supplemental nutrition.
 

Q. What are Tre-en-en Grain Concentrates?

A. At the foundation of Formula IV and Formula IV Plus is Tre-en-en Grain Concentrates. This unique and exclusive whole-food blend of extracts from wheat, rice, and soy “feeds your cells” with important phytonutrients. Developed and introduced by GNLD in 1958, Tre-en-en Grain Concentrates is the original phytonutrient supplement. It provides phyto-lipids, including omega-6 and omega-3 fatty acids essential for optimum health and cellular function, plus the plant sterols beta-sitosterol, gamma-oryzanol, stimasterol and campesterol.

Besides optimizing cellular nutrition, plant sterols may have other beneficial effects as well. These include reducing cholesterol levels, lowering the risk of atheroscelerosis and inhibiting tumors. Octacosanol, which is a closely related component, is also included to aid in critical biological functions.

Store in a cool, dry place, away from direct sunlight.
Packaged with safety seal.
 
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• 100% biodegradable and phosphate-free. Complete. Ingredients are blended with liver and soy lecithin to provide the entire family of B-vitamins (including 400 mcg of folic acid).

• Biologically-bound yeast source for natural completeness.

• Balanced natural ratios; avoids a high intake of one which may induce a deficiency in others.

• Threshold Control formula provides sustained release of B-complex nutrients over 6 hours.

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* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Lipids and sterols provide critical support for the healthy cellular uptake of nutrients and cellular export of waste and metabolites.*

TRE-EN-EN Grain Concentrates “feed your cells” with an exclusive whole-food blend of extracts from wheat, rice and soy. It provides phyto-LIPIDS, including Omega-6 and Omega-3 fatty acids, phyto-STEROLS beta-sitosterol, gamma-oryzanol, stimasterol, and campesterol, plus octacosanol.

Contains no cholesterol. Cold pressed and cold processed to preserve nutritional value.

• Complete lipid and sterol profile of wheat, rice, and soy.

• Diverse phytonutrient extracts from staples used around the globe supply essential nutrients, such as omega-3 and omega-6 fatty acids, for optimum cellular function.

• Scientifically proven to promote efficient nutrient utilization needed for cardiovascular growth and development.*

• Replaces important sterols stripped from processed foods, including beta-sitosterol, gamma-oryzanol, stimasterol and campesterol, plus octacosanol.

• Cold-pressed and cold-processed to preserve nutritional value.

• Cholesterol-free, yeast-free.

SUGGESTED USE: (Adults) 1-3 capsules daily with meals.

Non active: gelatin, glycerin, yellow beeswax, water, rice bran powder, wheat germ powder, titanium dioxide, natural color and mixed non-alpha tocopherol

Store in a cool, dry place, away from direct sunlight. Packaged with safety seal.

TRE-EN-EN FOR CELLULAR EFFICIENCY

Our bodies are composed of trillions of cells which must work efficiently if we are to stay healthy. How do cells stay healthy? The key is their membranes. Like bodies, cells must take in nutrients and eliminate wastes. Every cell in the body is surrounded by a lipid membrane with the discretionary power to allow only needed nutrients to enter the cell. By the same token, it allows only waste material and metabolic products (hormones, enzymes, neurotransmitters, etc.) to exit. Deficiencies of lipids, sterols, and amino acids can compromise the discretionary power of cells. Cells can become “starved” (inhibited in their ability to take in substances) even though nutrients are available. And they can become “constipated” (inhibited in their ability to eliminate accumulating waste products or export metabolites). Under these conditions, cells work inefficiently, expending more energy than healthy cells would to get the same results.

Tre-en-en Grain Concentrates supply essential lipids and sterols to promote the efficient functioning of cells, glandular systems, and the entire body. Remember, we are only as healthy as our cells, and Tre-en-en strengthens the lipid/sterol “link” in our “Chain of Life,” supporting cellular health and vitality.

PROVEN EFFECTIVE IN LABORATORY TESTS Scientists have known for years that lipids and sterols are required for normal cellular functioning, glandular activity, and overall growth and development. A series of studies conducted at Texas A&M University in 1987 confirmed the nutritional benefits of Tre-en-en Grain Concentrates (lipids and sterols from wheat, rice, and soybeans). The seven-week studies looked at growth, development, maturation, and glandular activity of young rats fed either a standard control diet (laboratory chow fortified with vitamins and minerals) or the standard diet with Tre-en-en Grain Concentrates substituted for the lipids used in the standard chow. Animals were allowed to eat as much as they wanted; both chows had the same caloric content. (All tests were performed and all animals were housed and cared for with the highest level of concern for the health and well being of the animals. No animals were exposed to conditions of pain or suffering.)

When the amount of food consumed was correlated with the amount of weight the rats gained, the researchers found that the Tre-en-en-fed animals displayed superior growth and development, indicating that their bodies made better use of the available nutrients. In all cases the Tre-en-en-fed group grew faster, achieved maturity faster, and had better overall development than the group that was fed the control diet. In addition, the cardiovascular systems of the Tre-en-en-fed group were better developed, and their adrenal activity — an indicator of their energy levels and ability to respond to stress — was greater.

OVERALL GROWTH AND DEVELOPMENT Animals fed diets fortified with Tre-en-en Grain Concentrates attained a greater level of overall growth and development than did animals fed a control diet.

CARDIOVASCULAR DEVELOPMENT Animals on the Tre-en-en diet displayed greater cardiovascular development than did animals fed the control diet. Cardiovascular development (measured by heart weight) paralleled overall growth and development, indicating that larger animals were not “fatter” but instead were more fully developed.

NUTRIENT UTILIZATION EFFICIENCY Compared to animals on a control diet, the animals fed Tre-en-en Grain Concentrates demonstrated superior growth, development, and maturation, even though each test group consumed the same amount of calories. This result indicates that the Tre-en-en-fed animals utilized nutrients from food more efficiently than did control animals.

GLANDULAR ACTIVITY Glandular activity (as measured by liver glycogen levels) was almost twice as high in the Tre-en-en-fed rats compared to the control animals. This result indicates that the Tre-en-en-fed animals had higher energy levels and were better prepared to handle stress. Unique and exclusively available from GNLD, Tre-en-en provides lipids and sterols cells need to be their healthy best! With cold-pressed, cold-processed extracts and concentrates from wheat germ, rice bran, and soybeans, Tre-en-en helps assure good nutrition at the cellular level.

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Science has shown that a special group of nutrients called polyphenols, drawn from an equally special group of foods referred to as Super Fruits, plays a wide range of critical roles in supporting and maintaining optimal health, longevity, and cognitive capacity throughout life.

This research tells us that when these polyphenols are absent from or deficient in our diets, aging processes are accelerated and disease risk is higher. Conversely, when they are abundant in the diet, aging is slowed and disease risk is lowered.

Why TRÉ?

Combining Super Fruits with Superb Science
• Potent and unique combination of the purest extracts of Pomegranate, Acai berry, and Green Tea, combined with our proprietary Inflox berry blend, Tré is enhanced with resveratrol and alpha-lipoic acid, and is sweetened naturally with the nectar from the Agave cactus.
• Standardized amounts of active ingredients such as punicalagins in Pomegranate and polyphenols in Green Tea assures you a powerful measure of the most potent bioactive essence in each serving.
• Drawn from a broad spectrum of powerful Super Fruits, Tré assures you the nutrient diversity your body needs—and nature intended!
• Conceived and created by GNLD’s Scientific Advisory Board— world-renowned experts in creating whole-food based, scientifically proven products.
• Delicious and concentrated, from the first sip, you will experience the refreshing taste and the invigorating potency of the active ingredients—for living long and living well.
• Refreshing beverage with a low glycemic response

The GNLD Difference

Tré is a perfect reflection of GNLD’s product philosophy — Based in Nature, Backed by Science. Its standardized and focused nutrient diversity is a pure expression of nature’s plan for human nutrition.

Tré is:

• Potent and unique, a combination of the purest extracts of Pomegranate, Acai berry, and Green Tea, along with our proprietary Inflox berry blend, enhanced with resveratrol and alpha-lipoic acid. Tre’ is sweetened naturally with the nectar from the Agave cactus.

• Powerful. With standardized amounts of active ingredients such as punicalagins in Pomegranate and polyphenols in Green Tea, you are assured a powerful measure of the most potent bioactive essence in each serving.

• Delicious and concentrated. Tre’ is not just juice. It is a unique combination of nature’s most health-enhancing ingredients, blended with powerful, anti-aging antioxidants to bring you a pure essence of nature, based on a foundation of science. From the first sip, you will experience the refreshing taste and the invigorating potency of the ingredients.

• Healthy and smart, a revitalizing essence with a low glycemic response.

Your SAB Guarantee

Tre’ was conceived and created by GNLD’s scientific advisory board-world-renowned experts in whole-food nutrient identification, extraction, and concentration, committed to delivering scientifically proven products for lifetime health and vitality. All of the ingredients in Tre’ were carefully selected based on evidence of the nutrients they contain, and the specific roles, individually and synergistically, that they play in delivering powerful benefits.

Scientific References

Arts ICW and Hollman PC. Dietary Polyphenols and Health: Proceedings of the 1st International Conference on Polyphenols and Health: Polyphenols and disease risk in epidemiologic studies. Am J Clin Nutr Jan 2005; 81: 317S – 325S.

Joseph JA., et al., Reversing the deleterious effects of aging on neuronal communication and behavior: beneficial properties of fruit polyphenolic compounds. Am J Clin Nutr Jan 2005; 81(1): 313S-316.

Summer MD, Elliott-Eller M, Weidner G, Daubenmier JJ, Chew MH, Marlin R, Raisin CJ, and Ornish D. Effects of Pomegranate Juice Consumption on Myocardial Perfusion in Patients with Coronary Heart Disease. American Journal of Cardiology 2005; 96: 810-814

Pantuck, AJ, et al. Phase II Study of Pomegranate Juice for Men with Rising Prostate-Specific Antigen following Surgery or Radiation for Prostate Cancer. Clin Cancer Res 2006; 12: 4018-4026.

Thorpe JF, Jain S, Marczylo TH, Gescher AJ, Steward WP, Mellon JK. A review of phase III clinical trials of prostate cancer chemoprevention. Ann R Coll Surg Engl 2007; 89: 207–11

Mertens-Talcott SU, et al. Pharmacokinetics of Anthocyanins and Antioxidant Effects after the Consumption of Anthocyanin-Rich Acai Juice and Pulp (Euterpe oleracea Mart.) in Human Healthy Volunteers. J. Agric. Food Chem, 2008; 56: 7796-7802

Spencer WM. et al. Blueberry-induced changes in spatial working memory correlate with changes in hippocampal CREB phosphorylation and brain-derived neurotrophic factor (BDNF) levels. Free Radical Biology and Medicine 2008; 45 (3): 295-305.

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